摘要
目的探讨奥美拉唑对十二指肠溃疡(DU)患儿T淋巴细胞亚群的影响。方法采用流式细胞术检测十二指肠溃疡患儿外周血T淋巴细胞亚群。结果治疗前42例DU患儿与对照组比较CD3+、CD8+间差别无显著性意义(P>0·05),CD4+、CD4+/CD8+与对照组间差别有显著性意义(P<0·01、P<0·05);治疗后治疗组CD4+、CD4+/CD8+比值较治疗前显著降低(P<0·01),与对照组间差别无显著性意义(P>0·05)。结论奥美拉唑能恢复儿童DU异常的细胞免疫功能。
Objective To explore the effect of Omeprozole on T - lymphocyte subsets in children with duodenal ulcer. Methods T - lymphocyte subsets with duodenal ulcer （DU） were measured by flow cytometry. Results The number of CD4^＋ positive cells and the ratio of CD4^＋/CD8^＋ in T - lymphocyte subsets of 42 children with DU was significantly higher than that in 28 control children （ P 〈0.01, P 〈0. 05 ）, but there were no differences in the number of CD3^＋, CD8^＋ positive cells of these children between two groups （ P 〉 0. 05） ; after the triple therapy with Omeprozole, elarithromycin and metronidazole, the number of CD4^＋ positive cells and the ratio of CD4^＋/CD8^＋ were decreased and significantly lower than that before the treatment in children with DU, but there was no significant difference between two groups after the treatment （ P 〉 0.05 ）. Conclusion Omeprozole can recover the abnormal cell immune function of the children with DU.
出处
《中国全科医学》
CAS
CSCD
2005年第24期2062-2063,共2页
Chinese General Practice
