摘要
目的探讨慢性阻塞性肺疾病(COPD)患者血清瘦素与骨密度相关关系。方法采用横断面研究纳入本组的COPD患者26例,健康对照组25例,应用放射免疫检测方法检测血清瘦素,双能x线吸收测定仪行腰椎(L2-4)、股骨颈(Neck)、股骨三角(W ard’s)及股骨大转子(Troch)骨密度检测。结果(1)COPD患者血清瘦素较健康对照组低(P<0.001);(2)COPD组,病程>10年或有过呼吸衰竭患者的血清瘦素高于病程<10年或无呼吸衰竭的患者(P均=0.006);COPD患者血清瘦素与L2-4(r=-0.56,P=0.003)、Neck(r=-0.55,P=0.004)、W ard’s(r=-0.48,P=0.013)及Troch(r=-0.45,P=0.022)骨密度存在明显负相关。结论瘦素可能参与COPD骨矿含量丢失机制发生,且血清瘦素水平可作为COPD骨量丢失的预测因子。
Objective To explore whether serum leptin concentration has any correlation with bone mineral density（BMD） in COPD patients. Methods In a cross-sectional study,26 male patients with COPD and 25 male healthy people were recruited. Serum leptin levels were determined by radioimmunoassay（RIA） and BMD of lumbar spine （ L24 ） ,nondominant femoral neck（Neck） ,ward＇s triangle（ Ward＇ s） and greater trochanter （Troch） were measured by dual-energy x-ray absorptiometry（DEXA）. Results The BMD of L24, Neck, Ward＇ s and Troch in patients with COPD were all significantly decreased compared to that of healthy people（ P 〈 0.01orP 〈 0.05 ）and the levels of serum leptin in the COPD patients were much lower than those in the healthy people（ P 〈 0.01 ）. In COPD patients the leptin levels with the COPD course I〉 10 years were much higher than those with 〈 10 years （P 〈 0.01 ）. Moreover, COPD pa- tients with respiratory failure had more increase levels of leptin compared to the patients without respiratory failure （ P 〈 0.01 ）. The levels of leptin in patiens with COPD were negatively correlated with L24 （ r = - 0.56,P 〈0.01） ,Ward＇s（r= -0.48,P 〈0.05） ,Troch（r = -0.45,P 〈0.05）and Neck（r= -0.55,P 〈 0.01）. Conclusion In COPD patients leptin may contribute to the pathophysiology of osteoporosis in COPD and serum leptin level might be regarded as a predictor of bone mineral loss in COPD patients.
出处
《临床内科杂志》
CAS
2005年第12期824-826,共3页
Journal of Clinical Internal Medicine
基金
国家中医药管理局青年基金项目(04-05JQ03)
关键词
瘦素
肺疾病
阻塞性
骨密度
预测因子
Leptin
Pulmonary disease, obstructive
Bone mineral density
Predictor
