摘要
目的:优选复方氟尿嘧啶凝胶的基质。方法:用正交实验法,以卡波姆-934、甘油、三乙醇胺(调pH)的配比为因素,每个因素选择3个水平,以凝胶在55℃水浴中的分层时间及物理外观为指标,用L9(34)正交表进行实验。结果:最优处方为:卡波姆-934为1.5%,甘油为10%,pH值为6.5。结论:按最优配比制备的复方氟尿嘧啶凝胶符合《中国药典》2000版项下的规定。
Objective： Optimization of formula composition for fluorouracil gelatin and physical stability investigation.Methods： According to the factors that affact the stability of gelatin ,orthogonal design was used ,carbomer- 934 , glycerol and trolmine were selected as variable factors.Trolamine was used to measure the acidity or alkalinity.Every factor excerpted three level,the guideline was glation in 55℃ water bath physical appearance and delamination time,table L9 （3^4）was used,Results： the optimun formula was： 1.5%carbomer,10% glycerol,PH was equal to 6.5.Conclusion： the preparation complies with the reqirement of Chinese pharmacopoeia 2000.
出处
《农垦医学》
2005年第3期168-170,共3页
Journal of Nongken Medicine
关键词
氟尿嘧啶
凝胶
正交实验
物理稳定性
fluorouraeil
gelatin
orthogonal design method
physical stability.
