摘要
目的探讨基质金属蛋白酶-2(MMP-2)及其相应的组织金属蛋白酶抑制剂-2(TIMP-2)在非小细胞肺癌(NSCLC)进展过程中的意义。方法应用免疫组化二步法检测17例正常肺组织、48例NSCLC组织中MMP-2、TIMP-2的表达。结果NSCLC中MMP-2、TIMP-2阳性表达率分别为47.9%、41.7%,高于正常肺组织,差异有非常显著意义(P<0.01)。MMP-2蛋白的表达与肿瘤淋巴结转移及TNM分期呈正相关;而TIMP-2的表达与上述因素的相关性不明显。结论MMP-2可以作为判断NSCLC恶性程度及预后的生物学指标。TIMP-2没有显示对肺癌的独立抑制作用,但与MMP-2表达平衡破坏可能是肿瘤浸润发展的重要因素。
Objective To explore the expressions of MMP-2 and TIMP-2 in non-small cell lung carcinoma （NSCLC） tissue and their significance. Methods Immunohistochemical method was used to detect the expressions of MMP-2 and TIMP-2 in 48 cases of NSCLC and 17 cases of normal human lung tissues. Results The expressions of MMP-2 and TIMP-2 in NSCLC were higher than those in normal human lung tissues. The expression of MMP-2 was positively associated with lymph node metastasis and its TNM stage, and the expression of TIMP-2 was not significantly associated with above mentioned factors. Conclusion MMP-2 can be used as a biological index to judge the pathological grade of NSCLC.
出处
《现代实用医学》
2005年第10期604-606,610,共4页
Modern Practical Medicine
关键词
癌
非小细胞肺
明胶酶A
金属蛋白酶2组织抑制剂
肿瘤转移
Careinma, non-small-cell lung
Gelatinase A
Tissue inhibitor-of metalloproteinase-2
Neoplasm metastasis
作者简介
钟国平（1965-），男，浙江省宁波市人，病理科副主任医师，发表论文6篇。
