摘要
目的探讨术前动脉灌注化疗在进展期结、直肠癌综合治疗中的作用。方法将进展期结、直肠癌80例随机分成术前动脉灌注化疗组(观察组)和常规治疗组(对照组)各40例,观察两组病人化疗后不良反应,术后复发和转移情况及3、5年生存率,并进行对比分析。结果观察组的骨髓抑制、胃肠道反应和急性肾功能损害的发生率与对照组比较无明显差异,局部复发率及肝脏、腹腔转移率低于对照组(P<0.05),观察组3年、5年生存率分别为87.5%、60.0%,明显高于对照组的64.5%、37.5%。结论对进展期结、直肠癌患者采用术前动脉灌注化疗的综合治疗,并不增加化疗的毒副反应,而能降低术后的复发率、转移率并能延长生存期。
Objective To study the value of preoperative arterial infusion chemotherapy in advanced colorectal carcinoma. Methods Eighty patients with advanced colorectal carcinoma were divided into 2 groups randomly. One group was treated with preoperative arterial infusion chemotherapy as observation group, and another with conventional treatment as control group. The side- effects to therapeutic regimens,occurrence of local metastasis, peritoneal metastasis, hepatic metastasis and other distant metastasis were observed. The 3 and 5 - year survival rates were analyzed. Results The side - effect rate of observation group was similar to those of the control group. Tne peritoneal and hepatic metastasis and local recurrence rates of the observed group were much lower than that of the control group （ P 〈 0.05）. The 3 and 5 - year survival rate of observation group （87.5% ,60.0% ） were much higher than those of the control group （64.5% ,37.5% ）. Conclusion Preoperative arterial chemotherapy for advanced colorectal carcinoma can decrease recurrence rote,metastasis rate and increase 3 and 5 - year survival rate.
关键词
结直肠肿瘤
动脉灌注化疗
Colorectal neoplasm
Arterial infusion chemotherapy
