摘要
本文应用葡聚糖包裹活性炭饱和分析法检测了４０例胃癌组织及其相应癌远隔胃粘膜组织中的雌激素受体（ＥＲ）和雄激素受体（ＡＲ）。结果显示：４０例胃癌组织中ＥＲ阳性率为１５％（６／４０），含量为１５３４＋１００．８ｆｍｏｌ／ｍｇ蛋白质，而在相应癌远隔组织中未检测到ＥＲ；胃癌组织中ＡＲ的阳性率为４５％（１８／４０），含量为１８８±１２．５ｆｍｏｌ／ｍｇ蛋白质，相应癌远隔组织中ＡＲ的阳性率为１５％（６／４０），含量为１９．１±９．４ｆｍｏｌ／ｍｇ蛋白质，而且癌组织中ＡＲ的含量高于相应癌远隔组织（Ｐ＜０．０５）；胃癌的ＡＲ、ＥＲ与患者的年龄、性别、肿瘤大小、肿瘤分型及细胞分化程度均无明显的相关性。
The activities of estrogen raceptor(ER)and androgen receptor(AR)were determinedby dextran-coated charcoal method in 40 cases of gastric cancer and pard-cancerous gastric tissues.The rcsult showed that ER was found in 6 cases(15.00%).the contents were 153.4 ± 1 00.8 fmol/mgprotein,hut wasn't found in any case of pardd-cancerous gastric tissue. AR were detected in 18 casesof gastric tissues. the conlents were 18.8±12.5 fmol/protein. and it was detectived in 6 cases(15.0%)of para-cancererous gastric tissues,the contents were 1 9.±9.4fmol/mg prolein. The ARcontent of the gastric cancer was higher than that of the para-cancerous gastric tissues(P<0.05).There was no correlation between concentration of AR,ER presented in gastric cancer and age,sex,Borrmann's type,size of primary tumor and the cell grade.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1996年第2期209-212,共4页
Chinese Journal of Pathophysiology
关键词
胃肿瘤
雌激素
受体
雄激素
Stomach· Neoplasms· Rcceptoro. estrogen· Receptors,androgen
