摘要
目的探讨乌鲁木齐地区维吾尔族和汉民族人白细胞抗原(HLA)B27阳性分布情况。方法用流式细胞术测定7家医院1220例疑似强直性脊柱炎(AS)患者外周血中淋巴细胞表面HLAB27抗原,并进行HLAB27阳性率分析比较。结果1220例疑似AS患者中,HLAB27阳性率男性(42.1%)明显高于女性(23.9%,χ2=41.91,P<0.01);汉族(44.2%)明显高于维吾尔族(27.2%,χ2=13.44,P<0.01);汉族5～19岁组、20～39岁组和60岁以上组明显高于维吾尔族(χ2=10.61,χ2=7.46,均P<0.01)。结论乌鲁木齐地区汉族与维吾尔族疑似AS患者中HLAB27阳性率存在民族、性别、年龄差异。
Objective To discuss distribution and regulation of human leukocyte antigen （HLA） B27 between Uygur and Han nationality in Wrumqi region. Methods Flow cytometry was used to detect HLA B27 on the surface of lymphocyte. Results HLA B27 positive rate of male （42. 1% ） was higher than that of female （23. 9% ,X^2 =41.91 ,P 〉0. 01 ）. The B27 positive rate of Han （44. 2% ）was higher than that of Uygur （27. 12% ,X^2 =13.44, P 〉 0.01 ）. There were significant difference between Han and Uygur nationality in the group who were 5 - 19-years old,20 -29 years old and 〉 60 years old,the positive rate of Han was higher than that of Uygur （X^2 = 10.61 X^2 =7.46,aU P 〈0.01）. Conclusions It as found that populative characteristics of HLA B27 distribution, especially significant in nationality and sex.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2005年第11期1163-1165,共3页
Chinese Journal of Laboratory Medicine
关键词
HLA
B27抗原
数据收集
HLA B27 antigens
Epidemiologic characteristics
作者简介
周伟一，获阳普杯优秀论文奖。男，1963年生，毕业于新疆维吾尔自治区人民医院护校。主要从事免疫和临检工作，参与的戊肝核酸探针研究获新疆科技三等奖
通讯作者：杨忠礼，电子信箱；yangzhongli_xj@163．com
