摘要
目的探讨胺碘酮长疗程个体化治疗室性心律失常的临床疗效和安全性。方法37例室性心律失常患者给予胺碘酮个体化治疗,疗程1年以上,观察治疗前和治疗后1年患者室性心律失常的有效控制率、QT间期变化以及不良反应。结果37例患者胺碘酮的维持量为(152±32)mgd,比推荐的用量(200～400mgd)要小,而胺碘酮治疗室性心律失常的有效率仍高达89.2%;QT间期轻度延长[(391±49)msvs(436±50)ms,P<0.05),不良反应少。结论胺碘酮长疗程个体化治疗室性心律失常的临床疗效确切,维持用量较小,相关的不良反应也减少。
objective To evaluate the clinical efficacy and safety of amiodarone in the treatment of the patients with ventricular arrhythrajas（VA） in long-course individualization.Methods thirty-seven patients with VA were treated with amiodarone for more than one year individually. The rate of effective controlling,the changing of QT intervals and the side-effects were observe before and after treatment with amiodarone for one year. Results The dose of maintaining of thirty-seven patients with VA was lower than that of common recommended daily dose[ （ 152 ± 32）rag vs 200 - 400mg respectively] and 89.2% of the patients with VA was controlled.QT intervals were increased slightly [（391 ± 49）ms vs （436 ± 50）ms, P 〈 0. 05 ]. The side-effects of amiodarone was lower. Conclusion Amiodarone is an effective and safe drug for the treatment of the patients with ventricular arrhythmias（VA） in long-course individualization. The dose of maintaining were lower and the side-effects were less.
出处
《广西医学》
CAS
2005年第11期1740-1741,共2页
Guangxi Medical Journal
关键词
室性心律失常
胺碘酮
个体化治疗
Ventricular arrhythmias
Amiodarone
Individually treatment
