摘要
目的:考察同一批冠心Ⅱ号组方药材在同一煎煮工艺条件下煎剂中有效成分含量的变异程度。方法:选择同一批组方药材,尽可能地控制煎煮过程的各个细节,测定5批次冠心Ⅱ号煎剂中有效成分的含量并计算其平均值。结果:以生药量计,丹参素为(0.773±0.0 656)mg/g,原儿茶醛为(36.591±3.0 590)μg/g,芍药苷为(2.655±0.2 454)mg/g,阿魏酸为(85.052±7.5 469)μg/g。结论:如果以批次间成分含量变异系数小于10%为标准,各有效成分含量均达到要求;如果以成分含量批次间无统计学差异的标准来判断,则需要将更多影响煎剂有效成分含量的因素纳入质量控制范畴。
OBJECTIVE： To investigate the variation degrees of the active components in the same batch No.Guanxin Ⅱ decoctions under the same decoction technics. METHODS： Crude drug of the same batch No.of the same formula was decocted,every decoction detail was tried to be kept under control, the contents of the active components in 5 batches of Guanxin II decoctions were determined and the mean value of which was calculated as well. RESULTS： In terms of the contents of crude drugs, those of tanshinol, protocatechualdehyde, peoniflorin and ferulic acid were respectively（0.773 ±0.0 656）mg/g, （36. 591±3.0 590）μg/g, （2. 655 ± 0.2 454） mg/g, （85. 052 ± 7.5 469） μg/g. CONCLUSION ： Referenced by the criterion that the content variation coefficient among different hatches of decoctions should be less than 10%, the contents of active components in each decoction were all up to the standards. Referenced by the criterion that there should be no statistical difference among different hatches of decoctions, more influential factors on the active components of decoctions should be brought into consideration in the quality control.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第22期1695-1696,共2页
China Pharmacy
基金
国家自然科学基金资助项目(30070912)
关键词
中药复方
煎剂
冠心Ⅱ号
质量控制
制剂学指标监测
Traditional Chinese Medicine complex prescription
Decoction
GuanxinⅡ
Quality control
Pharmaceuticalpharmacy index monitoring
作者简介
甘洪全,讲师,博士.研究方向：中药复方药动学.电话：029-83374555
黄熙,通讯作者：教授,博士研究生导师.研究方向：中药复方药动学.电话：029-83375958,E-mail：huangren@fmmu.edu.cn
