摘要
目的研究血清超敏C反应蛋白(hsCRP)与老年冠心病严重程度的关系,探讨hsCRP在冠心病患者中的临床意义。方法测定经冠脉造影确诊的117例老年冠心病患者的血清hsCRP浓度,其中稳定型心绞痛患者41例,不稳定型心绞痛患者62例,急性心肌梗死患者14例。以经冠脉造影排除冠心病的15例患者为正常对照组,比较各组间hsCRP的浓度。结果冠心病患者各亚组hsCRP浓度均较正常对照组(0.56mg/L±0.27mg/L)显著升高,P<0.001。冠心病各亚组中,不稳定型心绞痛组血清hsCRP浓度(7.38mg/L±5.73mg/L)显著高于稳定型心绞痛组(5.40mg/L±11.7mg/L),P<0.001;急性心梗组血清hsCRP浓度(32.75mg/L±23.16mg/L)又分别显著高于不稳定型心绞痛组及稳定型心绞痛组,P<0.001。结论血清hsCRP浓度与冠心病患者病情的严重程度有关,可作为临床冠心病患者病情严重程度的参考指标。
Objectives： To investigate the significance of the serum level of high-sensitivity C-reactive protein（hs-CRP） in patients with coronary artery diseases（CAD）. Methods：One hundred and seventeen patients diagnosed with CAD by coronary angiography were divided into three groups：stable angina （41 cases）, unstable angina（62 cases） and acute myocardial infarction （AMI, 14 cases）. Fifteen cases with normal angiography were treated as the control. All the samples were collected to measure the serum levels of hs-CRP. The serum levels of hs-CRP were compared among each group. Results.. The serum levels of hs-CRP in patients with CAD were significantly higher than those of the control （0.56mg/L ± 0.27mg/L）, P〈0.001. The serum level of hs-CRP in unstable angina group （7.38mg/L ± 5.73mg/L） was significantly higher than those in stable angina group （5.40mg/L ± 11.7mg/L）, P〈0.001. And the serum level of hs-CRP in AMI group （32.75mg/L ± 23. 16mg/L） was significantly higher than the above two guoups,P〈0.001. Conclusions：There is a close relationship between serum level of hs-CRP and the severity of coronary disease.
关键词
超敏C反应蛋白
冠心病
心绞痛
High-sensitivity
C-reactive protein
Coronary artery disease
Angina
