1Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS.Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev, 1999, 20:68～100.
2Mondal MS, Nakazato M, Matsukura S. Orexins(hypocretins): novel hypothalamic peptides with divergent functions. Biochem Cell Biol, 2000, 78: 299～305.
3Stanley BG, Ha LH, Spears LC, Dee MG 2nd. Lateral hypothalamic injections of glutamate, kainic acid, D, L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res, 1993, 613: 88～95.
5Vrang N, Phifer CB, Corkern MM, Berthoud HR. Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons. Am J Physiol Regul Integr Comp Physiol,2003, 285: R470～R478.
6Camina JP, Carreira MC, Micic D, Pombo M, Kelestimur F, Dieguez C, Casanueva FF. Regulation of ghrelin secretion and action. Endocrine, 2003, 22: 5～12.
7Asakawa A, Inui A, Kaga T, Katsuura G, Fujimiya M,Fujino MA, Kasuga M. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut,2003, 52: 947～952.
8Ukkola O, Poykko S. Ghrelin-peptide hormone that increases appetite. It opens new possibilities for the research on energy metabolism Lakartidningen, 2002, 99:2152～2153.
9Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N,Grove KL, Strasburger C J, Bidlingmaier M, Esterman M,Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P,Low M J, Sotonyi P, Friedman JM, Liu H, Pinto S,Colmers WF, Cone RD, Horvath TL The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron, 2003, 37: 649～661.
10Zhang Y, Proenca R, Maffei M, Barone M, Leopold L,Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994, 372: 425～432.
二级参考文献22
1Seeley R J, Blake K, Rushing P A, et al. The role of CNS glucagons-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride [J]. J neurosci, 2000,20(4) : 1616-1621.
2Ganaraja B, Jeganathan P S. Effect of basolateral amygdala and ventromedial hypothalamic lesions on ingestion and taste preference in rat [J]. Indian J Med Res ,2000,112:65-70.
3Van Rossum CT,Hoebee B,van Baak MA,Mars M,Saris WH,Seidell JC,et al.Variation in the leptin receptor gene,leptin,and weight gain in young dutch adults.Obes Res,2003,11:377-386
4Paul Cohen,Makoto Miyazaki,Nicholas D Socci,Aaron Hagge-Greenberg,Wolfgang Liedtke,Alexander A Soukas,et al.Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.Science,2002,297:240-243
5Udagawa Jun,Hatta Toshihisa,Naora,Hiroyuki,Otani,Hiroki PP,et al.Expression of the long form of leptin receptor (Ob-Rb) mRNA in the brain of mouse embryos and newborn mice.Brain Res,2000,868:251-258
6Wellhoener P,Fruehwald-Schultes B,Kern W,Dantz D,Kerner W,Born J,et al.Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans.J Clin Endocrinol Metab,2000,85:1 267-271
7Di Carlo C.Leptin and female reproduction.J Endocrinol Invest,2003,26:93-95
8Tommaselli GA,Di Carlo C,Nasti A,Giordano E,Pisano G,Pellicano M,et al.Effects of bilateral ovariectomy and postoperative hormonal replacement therapy with 17beta-estradiol or raloxifene on serum leptin levels.Menopause,2003,10:1 640-644
9Zitzmann M,Gromoll J,Von Eckardstein A,Nieschlag E.The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men.Diabetologia,2003,46:31-39
10Banks WA,Farrell CL.Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible.Am J Physiol Endocrinol Metab,2003,285(1):5-10
