摘要
目的:研究子宫内膜异位症(EM)患者血清血管内皮生长因子(VEGF)水平的动态变化及其在EM疗效和预后评价中的意义.方法:应用双抗体夹心酶联免疫吸附法分别检测正常健康妇女(正常组,35例)及子宫内膜异位症患者(EM组,65例,其中Ⅰ～Ⅱ期26例,Ⅲ～Ⅳ期39例)手术前后外周血清中VEGF的水平.结果:EM组术前血清中VEGF水平250.70±88.84 ng/L明显高于正常组103.20±49.18 ng/L(P＜0.01),Ⅲ～Ⅳ期内异症患者血清VEGF的水平305.02±69.74 ng/L显著高于Ⅰ～Ⅱ期169.21±36.12 ng/L(P＜0.01).术前血清中VEGF水平250.70±88.84 ng/L高于术后1周VEGF水平153.97±58.64 ng/L(P＜0.05).随访期间29例未复发的EM患者综合治疗结束后血清VEGF水平呈下降趋势,6例复发的EM患者综合治疗结束后血清VEGF水平呈增高趋势.结论:VEGF与EM密切相关,动态检测EM患者外周血VEGF的水平变化有可能作为EM疗效评价、复发及预后的重要指标.
Objective：To investigate the serial changes of serum vascular endothelial growth factor （VEGF） concentrations in patients with endometriosis and its significance in the evaluation of treatment efficacy and prognosis for these patients. Methods： Serum VEGF concentrations in 35 healthy women （normal group） and 65 patients with endometdosis （stage Ⅰ～Ⅱ 26 cases and stage Ⅲ～Ⅳ 39 cases） were measured by sandwich enzyme-linked immunoedsorbent assay （ELISA） before and after surgery. Results： The level of VEGF in endometriosis group before surgery was 250.70±88.84 ng/L, which was significantly higher than in the control group （103.20±49.18 ng/L） （ P〈 0.01 ）. VEGF level of endometriosis stagesⅢ～Ⅳ （305.02 ± 69.74 ng/L） was significantly higher than that of stage Ⅰ～Ⅱ （169.21 ±36.12 ng/L） （P〈0.01）.The level of VEGF in endometriosis group before surgery （250.70 ± 88.84 ng/L） was significantly higher than that in one week after surgery （154.38 ± 49.52 ng/L） （ P 〈 0.05）. Of 35 follow-up patients,29 patients had no recurrence and VEGF level appeared dowrntread. But VEGF level in 6 patients with recurrence in the follow-up period re-elevated. Conclusions, These results suggest that VEGF concentration related closely with progression and malignant behavior of endometriosis, and serial determination of serum VEGF may be an important index for evaluation of efficacy, recurrence and prognosis for patients with endometriosis.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2005年第10期598-600,共3页
Journal of Practical Obstetrics and Gynecology
基金
广西自然科学基金项目(桂科自0135054)
