摘要
目的:研究重组人酸性成纤维细胞生长因子(rhaFGF)在破损皮肤表面给药时的生殖毒性。方法:从SD大鼠怀孕第6天起对破损皮肤连续给药10 d,剂量分别为3 600 U/cm2,1 800 U/cm2,900 U/cm2,观察rhaFGF对大鼠的生育能力、胎鼠的生长发育及骨骼发育的影响。结果:大鼠破损皮肤外用相当于有效剂量603、0和15倍的rhaFGF对母体的毒性、胚胎毒性和致畸作用均无明显的影响。结论:在相当于有效剂量60倍的剂量下使用rhaFGF对母体和胎儿是安全的。
AIM：To investigate the toxicity of recombinant human acidic fibroblast growth factor （rhaFGF） on reproduction system in rats. METHODS： The damaged skin on rats was treated with rhaFGF at the dose of 3 600 U/cm^2, 1 800 U/cm^2 and 900 U/cm^2 respectively, once a day for 10 days successively. The fertile activity of mother rats and growing development of embryo was observed. RESULTS ： No significant differences in the toxicity of mother rats, or embryo teratogenesis were found between each of group even when treated with rhaFGF at 60-fold effective doses. CONCLUSION： The safety on pregnant rats and the fetus upon treatment on topical damage skin with rhaFGF of doses up to 60-fold effective dose was confirmed.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2005年第5期461-463,共3页
Journal of China Pharmaceutical University
基金
国家高技术研究发展计划("八六三"计划)资助项目(No.2002AA2Z3318
2004AA2Z3C60)
广州市科技计划资助项目(No.2005J1-C0151)~~
关键词
重组人酸性成纤维细胞生长因子
生殖毒性
皮肤用药
Recombinant human acidic fibroblast growth factor
Toxicity on reproduction system
Transdermal
作者简介
【通讯作者】Tel：020—85220850 Fax：020—85224766 E—mail：xiaokunli@163．net
