摘要
利用表面活性剂C12E10水溶液在温度高于浊点时形成两相的行为对溶液中痕量利尿剂Furosemide进行了分离特性的研究，考察了盐、表面活性剂、Furosemide的浓度以及温度的影响。加入硫酸钠可将C12E10溶液的浊点降至常温（20℃），有利于浊点萃取操作。提高盐浓度有利于提高Furosemide的富集倍数，但对萃取效率几乎没有影响；提高初始溶液中的C12E10浓度将降低Furosemide富集倍数，提高萃取效率。在30℃～50℃之间，平衡温度的升高有利于提高Furosemide富集倍数。在温度为40℃时，采用2g·L^-1，C12E10和125g·L^-1硫酸钠体系，富集倍数为165．3倍，相体积比为0．0037。
A cloud point extraction process （CPE） utilizing polyoxyethylene 10 lauryl ether （C12E10） was developed to extract the diuretic, Furosemide. The effect of the concentrations of sodium sulfate,C12E10,and Furosemide as well as the temperature on the CPE behavior were investigated. The CPE process was improved by reducing the cloud point of the surfactant solution at ambient temperature with sodium sulfate. The preconcentration factor increases with the salt concentration, but the Furosemide extraction efficiency is independent of the salt concentration. Increasing the initial C12E10 concentration improves the extraction efficiency, but reduces the preconcentration factor by quickly increasing the coacervate phase mass. The tests also show that the preconcentration factor could be enhanced by increasing the temperature to 30℃ ～ 50 ℃. A high preconcentration factor of 165.3 and coacervate to aqueous phase volume ratio of 0. 003 7 are achieved using 2 g·L^-1 C12E10 and 125 g·L^-1 sodium sulfate at 40℃.
出处
《清华大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2005年第9期1240-1243,共4页
Journal of Tsinghua University(Science and Technology)
基金
北京市科技三项资助项目(GYYZ0004029040211)
关键词
浊点萃取
利尿剂
富集
cloud point extraction diuretic preconcentration
作者简介
黄焱（1980-），男（汉），安徽，博士研究生。
通讯联系人：秦炜，副教授，E-mail：qinwei@mail．tsinghua．edu.cn
