摘要
目的:探讨非小细胞肺癌(non-smallcell lung cancer,NSCLC)患者手术前后血清中内皮抑素(endostatin)和血管内皮生长因子(vasular endothelial growth factor,VEGF)水平的动态变化规律及两者水平变化的相关性。方法:用ELISA法检测46例NSCLC患者手术前后血清中endostatin和VEGF的水平。结果:1)NSCLC患者术后7d血清endostatin水平为(23·41±5·12)ng/mL,显著高于术前[(20·85±4·56)ng/mL]和术后1d[(18·89±4·67)ng/mL]血清endostatin水平,P值分别为0·011和0·000;术后7d血清VEGF水平为(3·75±0·71)ng/mL,显著高于术前[(1·72±0·46)ng/mL]和术后1d[(2·22±0·58)ng/mL]血清VEGF水平,P值均为0·000。2)NSCLC患者术前血清endostatin与VEGF水平呈非常显著负相关,r=-0·380,P=0·009。3)NSCLC患者术后7d血清endostatin水平与VEGF水平呈非常显著正相关,r=0·351,P=0·017。结论:NSCLC患者手术前、后血清endostatin和VEGF水平存在动态变化,且两者手术前后的水平变化有显著相关性,检测NSCLC患者手术前后血清中endostatin和VEGF水平可能是进一步预测肺癌恶性行为的有用指标。肿瘤防治杂志,2005,12(19)
OBJECTIVE： To study the perioperative dynamics of serum levels of endostatin and VEGF in non-small cell lung cancer （NSCLC） patients and the dependability between them. METHODS： The perioperative serum levels of endostatin and VEGF were detected in 46 patients with NSCLC by ELISA mothod. RESULTS： 1 ）The serum levels of endostatin in NSCLC patients on the 7th postoperative day （23.41±5.12） ng/mL were significantly higher than those before operation （20.85 ± 4. 56） ng/mL（P= 0.011） and on the 1st postoperative day [（18.89 ± 4.67 ng/mL）], P = 0.000; the serum levels of VEGF in NSCLC patients on the 7th postoperative day （3.75± 0.71 ） ng/mL were also significantly higher than those before operation （1.72±0.46） ng/mL （P=0.000） and on the 1st postoperative day （2.22±0.58） ng/mL,P=0. 000.2）The preoperative serum levels of endostatin were highly negative correlated with serum VEGF levels in NSCLC patients,r=-0. 380, P=0.009. 3）The serum levels of endostatinon the 7th postop erative day were highly positive correlated with serum VEGF levels in NSCLC patients, r = 0. 351, P = 0. 017. CONCLUSIONS： The perioperatively dynamics of serum levels of endostatin and VEGF in NSCLC patients exists and the dependability between them is conspicuous. The perioperative serum levels of endostatin and VEGF in patients with NSCLC might be helpful to evaluating the biological behavior of lung cancer.
出处
《肿瘤防治杂志》
CAS
2005年第19期1441-1444,共4页
China Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(30070333)
关键词
癌
非小细胞肺/代谢
癌
非小细胞肺/病理学
血管内皮生长因子A/血清
内皮抑素类
酶联免疫吸附测定
carcinoma,non-small cell lung/metabolism
carcinoma.non-small cell lung/pathology
vascular endothelial growth factor A/serum
endostatins
enzyme-linked immunosorbent assay
作者简介
刘颖,男,河北邯郸人,博士,主治医师,主要从事肺癌的基础与临床研究工作.Tel：86-531-85186387 E-mail：liumike_2000@sohu.com.
通讯作者：周清华,男,四川自贡人,硕士,博士生导师,教授,主任医师,主要从事肺癌的基础与临床研究工作.Tel：86-28-85422584 E-mail：zhouqh@mail.sc.cninfo.net .
