摘要
A型流感病毒片段8编码的NS1蛋白是病毒复制和传播的重要调节蛋白。它含有3个功能区,即RNA结合区,eIF4GI结合区和效应区。NS1蛋白在A型流感病毒感染细胞中高水平表达,它的主要功能是抑制NF-κB(nuclear factor-κB)活化和IFN(inter-feron)-α/β介导的抗病毒作用,抑制Jun N末端激酶(jun N-terminal kinase,JNK)和AP-1(activating posttranslation)转录因子活化;下调病毒感染细胞凋亡;促进病毒基因表达,抑制宿主mRNA加工和转运。NS1蛋白的深入研究,为今后预防和治疗A型流感病毒寻找突破口。
Encoded by segment 8 in Influenza A virus, NS1 protein was a viral important regulator that Induced virus replication and spreading. It contained three function regions： RNA-binding , eIF4GI-binding and effect region. NS1 protein was expressed at high levels in virus-infected cells. Its functions includedpreventing activation of NF-κB and induction of α/β interferon;inhibiting activation of JNK and AP-1 transcription factors; down-regulating cell apoptosis; enhancing virus gene expression and inhibiting cellular mRNA processing and nucleocytoplasmic export. So the study on NS1 protein would find the solution for preventing and curing influenza A virus in the future.
出处
《动物医学进展》
CSCD
2005年第9期31-33,共3页
Progress In Veterinary Medicine
作者简介
魏宏（1978-），女，内蒙古海拉尔人，实习研究员，主要从事病毒免疫学研究。
