摘要
建立了离子对高效液相色谱法,测定氧氟沙星滴眼液中苯扎氯铵的含量。采用C18色谱柱,以0.02mol/L庚烷磺酸钠溶液(含0.1%三乙胺,pH3.45±0.1)-乙腈(35∶65)为流动相,检测波长210nm,柱温40℃。苯扎氯铵在10～70μg/ml浓度范围内线性关系良好(r=0.9997),方法平均回收率100.1%。
The ion pair-HPLC method for determination of benzalkonium chloride in ofloxacin eye drops was established. A C18 column was used with the mobile phase of 0.02mol/L sodium 1-heptanesulfate solution （containing 0.1% triethylamine, pH 3.45±0.1）-acetonitrile （35：65）, at the detection wavelength of 210nm and the column temperature of 40℃. The calibration curve of benzalkonium chloride was linear in the concentration range of 10 - 70μg/ml （r=0.9997）. The average recovery was 100.1%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第9期564-566,共3页
Chinese Journal of Pharmaceuticals
作者简介
陈秋芬（1960），女，工程师，从事药物分析研究。Tel：021-50272815；Fax：021-50273032；E—mail：arctiin@126．com
