摘要
目的:探讨新生儿期先天梅毒的临床表现特点。方法:总结分析36例新生儿期先天梅毒,观察患儿临床及实验室检查的改变。结果:无症状新生儿期先天梅毒占61%;新生儿期先天梅毒症状和体征主要有皮疹、肝脾肿大、肺部感染。36例患儿中,早产儿13例(36%),新生儿死亡5例(14%),血清学USR、TPPA、19SIgM-TPPA检测结果均为阳性,肝功能异常23例(64%),肾功能异常22例(61%)。结论:新生儿先天梅毒的诊断须结合临床体征、实验室诊断结果以及母亲的病史进行综合分析;妊娠梅毒患者应及时发现、诊断并给予规范治疗,才能有效地阻断先天梅毒的发生。
Objective： To characterize the clinic manifestations and understand the features of neonatal congenital syphilis. Methods： The clinical and laboratory data of 63 neonetal congerntal syphilis were analysed. Results： Brief clinical data were： premature delivery 36% , death 14% , and asymptomatic congenital syphilis 61%. Clinical signs and symptoms of these cases included skin rashes, pulmonary infection, enlargement of liver and spleen and blood abnormalities. All cases showed positive results of TRUST, TPPA and 19S - IgM - TPPA. Twenty - three cases had liver function damage. Twenty- two cases had renal function damage. Conclusions： Neonatal congenital syphilis should be diagnosed according to the clinic history, symptoms and the results of laboratory tests of the mothers and their children; typical skin symptoms can be used to diagnose neonatal congenital syphilis, but most cases are asymptomatie （22/36, 61% ）. In order to control the occurrence of neonatal congenital syphilis, antenatal routine screening and treatment for pregnant syphilis must be strengthened.
出处
《岭南皮肤性病科杂志》
2005年第3期205-206,209,共3页
Southern China Journal of Dermato-Venereology
