摘要
通过对四家综合医院儿科病房为期1年的药物不良反应协作监测,对1856例住院病人的药物不良反应进行了前瞻性观察。发现107例发生了药物不良反应,发生率为5.8％,其中A型反应为79例(73.8％),B型28例(26.2％);药物不良反应致停药者48例,需处理者31例,药物致死者1例,致住院治疗者27例。不良反应发生率与住院时间、共用药物、疾病构成有关。小儿某些解剖生理特点对不良反应发生有显著影响。通过多中心性监测的实践,认为在一般集中监测要求的基础上,建立协调中心统一判定标准和培训参与人员是协作监测成功的关键。
Hospitalized children were monitored in paediatric wards in four general hospitals from Mar. 1992 to Feb. 1993 in a cooperative program. There were 107 cases of adverse drug reactions identified in 1856 hospitalized children (5. 6%). Type A and B reactions accounted for 73.8% and 24.1% of whole ADRs respectively. 48 cases of ADRs required discontinuation of therapy, and 31 cases needed to be treated with other drugs. 21 cases were hospitalized due to ADRs. Incidence of'ADRs was closely related to the duration of hospitalization, the number of drugs administered, diseases inflicting the juvenile patients, and some anatomic and physiological features of children. The key to success of the multi-center monitoring of ADR was establishing cooperative center, unifying diagnosis standards, and training personnel for monitoring ADRs.
出处
《药物流行病学杂志》
CAS
1996年第1期16-19,共4页
Chinese Journal of Pharmacoepidemiology
基金
河南省医药卫生重点资助课题
关键词
药物不良反应
监测
儿童
儿科
病房
药物副作用
Adverse drug reactions monitoring
Hospitalized children
Paediatric wards
