摘要
目的介绍人工神经预构的物理材料、化学基质及生物种子细胞等方面的进展。方法广泛查阅近年相关研究文献,并重点讨论人工神经预构在物理材料、化学基质及生物种子细胞等方面的成果和目前存在的问题。结果聚乳酸、聚羟基乙酸的聚合物及其复合物、透明质酸和戊二醛的聚合物、聚氯乙酸、聚丙烯的聚合物,均是生物相容性良好且可降解的人工神经材料;人工神经管的多腔化和神经管道上孔隙率的设计有益于神经再生;激活的雪旺细胞是人工神经良好的种子细胞;合适的化学基质如层粘蛋白和藻胶可促进神经的再生。结论只有在神经再生的机制和人工神经的物理材料、化学基质和生物种子细胞等方面的研究均取得突破性进展时,理想的人工神经才有可能最终构制成功。
Objective To explore the advance in physical materials, chemical matrix, and biological seed cells for fabricating artificial nerve. Methods Recent literature relevant to artificial nerve, especially the achievement in physical material, chemical matrix and biological seed cells for fabricating artificial nerve, were extensively reviewed. Results Polymers of polylactic acid or polyglycolic acid and their polymer, polymer of hyaluronic acid and glutaldehyde, polymer of polyacrylonitrile and polyvinylchloride were artificial nerve materials with the properties of good biocompatibility and biodegradation, A conduit with multichannel and high percentage of pores was beneficial to the regeneration of nerve, The activated Schwann cells were excellent seeds of artificial nerve. A suitable chemical matrix, such as laminin and alginate, could promote the regeneration of nerve. Conclusion The successful fabrication of artificial nerve lies in the advance in the mechanism of nerve regeneration and physical material, chemical matrix and biological seed cells.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2005年第9期755-757,共3页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
组织工程
人工神经管
雪旺细胞
细胞外基质
Tissue engineering Artificial nerve conduit Schwann cell Extracellular matrix
作者简介
劳杰，教授，博士导师，研究方向：周围神经的损伤与修复，E—mail：jlao@public4．sta．net．cn
