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螺内酯联合美托洛尔治疗慢性充血性心力衰竭疗效分析 被引量:2

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摘要 目的:评价螺内酯联合美托洛尔治疗慢性充血性心力衰竭(CHF)的临床疗效和安全性。方法:将56例CHF患者随机分为常规治疗对照组26例和联合治疗观察组30例,两组患者均给予常规抗CHF治疗,观察组在常规治疗基础上加用螺内酯20~40mg/d和美托洛尔12.5~50mg/d,疗程8周。治疗前后分别测定心率、血压、血清钾离子浓度和肾功能,彩色多谱勒超声测量射血分数、每搏量、心脏指数,判定疗效的终点事件为临床心功能状况。结果:螺内酯联合美托洛尔使CHF患者心率减慢、血压改善(P<0.05),彩色多谱勒超声复查显示射血分数、每搏量、心脏指数较对照组明显提高(P<0.05),临床疗效心功能改善明显多于对照组(疗程结束后未发现高血钾,血肌酐、血尿素氮治疗前后无明显变化)。结论:螺内酯和美托洛尔治疗CHF是非常有益的,其副作用小、安全,近期疗效肯定,值得推广。
出处 《内蒙古医学杂志》 2005年第9期837-838,共2页 Inner Mongolia Medical Journal
作者简介 张健(1971-),女,辽宁省锦州市人。本科,主治医师。
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