摘要
目的探讨脑微出血(CMBs)与血管性认知功能障碍之间的关系及CMBs引起血管性认知功能障碍的机制。方法以头颅MR-GRE序列见微出血灶者为阳性病例组共47例,选取头颅GRE序列未见微出血灶患者47例符合入选及排除标准者作为对照组行神经心理评估。结果 CMBs阳性组的MoCA总分及执行功能、命名、计算、语言、抽象概括、回忆评分均明显低于对照组。各级CMBs组MoCA总分、执行功能、语言、抽象概括、记忆评分与0级组比较差异均有统计学意义(P<0.05),CMBs1、2、3级组语言及计算得分组间差异有统计学意义(P<0.05)。CMBs数目与总分、执行功能、语言、抽象概括呈负相关。结论 CMBs存在与否及数目和患者认知功能损害密切相关,CMBs数目越多,认知功能损害越明显。
Objective To investigate the relationship between the cerebral microbleeds (CMBs) and vascular cognitive impairment,and mechanism that CMBs causes vascular cognitive impairment.Methods Forty-seven micro-hemorrhage patients on MR-GRE sequences composed positive group,and 47 patients selected without micro-hemorrhage in the GRE sequence and meet the selection and exclusion criteria as control group.Both two groups took assessment of MoCA scale inspection.Results MoCA total scores and executive functions,naming,calculation,language,Abstraction,recall scores of CMBs positive group were significantly lower than those of control group. MoCA total scores,executive functions,language,Abstraction,memory scores between CMBs groups at all levels were significantly different(P<0.05),languages and calculated inter-group of CMBs 1,2,3-level were significant different(P<0.05). The number of CMBs was negative with total score,executive function,language,and Abstract.Conclusion The existence of CMBs and the number are closely related to cognitive dysfunction. The more of CMBs,the more of obvious cognitive impairment.
出处
《中国实用神经疾病杂志》
2010年第23期1-3,共3页
Chinese Journal of Practical Nervous Diseases
基金
常熟市科技局资助课题项目编号:CS200924
关键词
脑微出血
认知功能
蒙特利尔认知评估量表
Cerebral microbleeds
Cognitive function
MoCA(Montreal cognitive assessment scale)
