摘要
[目的]探讨nm23基因蛋白及组织蛋白酶D(Cath-D)在人乳腺癌组织中的表达及其与乳腺癌转移的关系.[方法]应用免疫组织化学染色方法观察43例乳腺癌组织的nm23基因蛋白及Cath-D的表达.[结果]nm23蛋白和Cath-D的表达与乳腺癌患者的年龄、绝经前后、肿瘤大小、组织学类型及临床病理分期无关,而与组织学分级、淋巴结转移、复发及转移、生存期有相关性.[结论]检测nm23基因蛋白与Cath-D的表达可作为乳腺癌研究的重要指标,对乳腺癌的转移与预后判定有重要意义.
OBJECTIVE To study the expressions of nm23 protein and cathepsin-D in breast cancer and its relationship with the metastasis.METHODS The expression of nm23 protein and cathepsin-D in 43 cases of breast cancer tissues were detected by using immunohistochemistry.RESULTS The expressions of nm23 protein and cathepsin-D were no significant relationship with the ages of patients,premenopause or postmenopause,size of tumor,histological type and the clinicopathological staging,but obvious association with histological grading,recurrence and transferation,lymph node metastasis and life span of patients.CONCLUSION The expressions of nm23 protein and cathepsin-D are as important makers for breast cancer,metastasis of breast cancer and prognosis of patients.
出处
《延边大学医学学报》
CAS
2010年第3期166-169,共4页
Journal of Medical Science Yanbian University
