摘要
用兔内毒素（ＥＴ）休克模型，对平均动脉压（ＭＡＰ）及支气管肺泡灌洗液（ＢＡＬＦ）中蛋白含量及吞噬细胞（ＰＡＭ）变化进行观测，探讨参附注射液（ＳＦ）对兔内毒素休克肺损伤的作用。结果：ＥＴ＋ＳＦ组ＭＡＰ虽下降，但２ｈ后开始上升，至６ｈ基本恢复正常，其与ＥＴ组比，Ｐ＜０．０５，与假手术组（Ｓｈａｍ组）比，ＥＴ２ｈ后差异无显著性；对ＢＡＬＦ中细胞总数和ＰＭＮ，ＥＴ＋ＳＦ组与ＥＴ组比较，差异显著（Ｐ＜０；０１）；蛋白定量，ＥＴ＋ＳＴ组与ＥＴ组间差异显著（Ｐ＜０．０５），而与Ｓｈａｍ组间差异不显著（Ｐ＞０．０５），证明参附注射液对肺损伤有明显的保护作用。
we studied the effects.of Shen fu injection(SF)onthe pulmonary injury due to endotoxic shock in
rabbits,the changes of mean arterial pressure(MAP),and of theprotin contents, macrphages and
neutrophils in broncho-alveolar lavage fluid(BALF) were assayfed in the modelof endotoxic
shock(rabbits).After endotoxin(ET)administration,MAP was also decreased in the ET+SFgroup、
but it began to increasc at 2 hrs and became al-most nomal at 6hrs. MAP was increased,
significantly(P< 0.05)compared with the controls, but its changewas insignifiant 2hrs after ET
administration(P>005)as compared with the “sham”. Total cells,macrophagesand neutrophils
in BALF of the ET+SF group were significantly reduced (P<0.01 ),and protein in BALF wasalso
markedly decreased(P< 0.05 ) compared with thecontrols; bwt the changes were insignificant(P<
0.05 )compared with the ” sham”,The results indicated thatSF had protective effects on the
pulmonary injury due toendotoxic shock in rabbits.
出处
《中国危重病急救医学》
CAS
CSCD
1995年第2期68-70,共3页
Chinese Critical Care Medicine
基金
江西中医学院国家自然科学基金
