摘要
中药提取物ＣＭ３６对小鼠Ｌｅｗｉｓ肺癌、小鼠肝癌（ＨＡＣ）抑瘤作用明显。实验初步表明，对ＨＡＣ的抑瘤作用优于抗癌药ＡＤＭ、ＴＳＰＡ、５ＦＵ以及ＶＰ－１６．似略优于ＭＭＣ。ＣＭ３６的产地不同，抑瘤作用不同，瘤株不同，抑瘤率亦异，ＣＭ３６对Ｓ１８０抑瘤作用差，动物品系不同，仰瘤效果有差别。对昆明种荷ＨＡＣ的抑瘤作用较强而对Ｂａｌｂ／ｃ荷ＨＡＣ的抑瘤作用差。用ＣＭ３６治疗小鼠移植性肿瘤，癌区内有淋巴样细胞及粒细胞与癌细胞紧密接触，癌细胞除坏死外，大量癌细胞退变，细胞浆与异染色质浓缩。ＣＭ３６还能使荷瘤小鼠总Ｔ细胞及其亚群升高，荷瘤小鼠（对照组）于后期Ｔ＿ｈ／Ｔ＿ｓ细胞之比有倒置现象而治疗组则没有，表明ＣＭ３６有免疫调节作用。
We have demonstrated
that CM36(a Chinese medicinal herb) was significantly
manifestedagainst Lewis pulmonary cancer in C57BL/6 mice and HAC in
Kunming mice by the inhibitionof the tumor. Our preliminary study in
mice with experimental subcutaneous(HAC)demonstrat-ed that the
inhibition of tumors were superior than ADM、TSPA、5Fu and VP-16 ,The
inhibitionmay be different from the places of production, the tumor
cell lines and the mice. CM36 ex-pressed a low inhibitory rate on S
180. In Kunming mice- bearing HAC, after therapy withCM36,the tumor
inhibitory rate were superior than in Balb/c-bearing HAC. The
immunologicalstudy in CM36 group showed an increase in splenic Thy 1,
2 lymphocytes and T Lymphocytesubsets of tumor-bearing mice. The
T_h/T_s ratio of control group was decrease in later period butno
significant change in the T_h/T_s ratio of therapeutical group.The
results show that treatmentwith CM36 express immunomodulation.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第2期109-113,共5页
Chinese Journal of Immunology
基金
国家自然科学基金
