摘要
氧氟沙星（ｏｆｌｏｘａｃｉｎ，ＯＦＬＸ）与头孢噻肟（ｃｅｆｏｔａｘｉｍｅ，ＣＴＸ）随机对照开放治疗肺部感染两组各３０例。年龄、性别、病种分类及病情轻重程度等资料无显著性差异（Ｐ＞０．０５）．结果显示两组有效率均为９６．６６％，细菌阴转率各为８６．６７％和８３．３３％，无显著性差异（Ｐ＞０．０５）。不良反应轻微，分别为３例（１０％）和４例（１３．３３％）。ＯＦＬＸ主要表现为精神兴奋和ＡＬＴ轻度增高，ＣＴＸ主要表现为静脉炎。体外抗菌活性表明两药对大多数革兰氏阴性菌和阳性茵均具有良好的抗菌活性。
A randomized and comparative study of ofloxacin (OFLX) and cefotaxime(CTX)for the treatment of pulmonary infections were reported. 60 patients were dividedevenly into 2 groups. group OFLX and group CTX. There were no significant differencesbetween the 2 groups in patient′s age. sex. the diseases suffered and their severity(P>0. 05). The Clinical efficacy as high as 96. 66%was found in both groups.The rates ofbacterial clearance from sputum were 86. 67%and 83. 33%respectively. The statisticaldifference was not significance(P>0.05). Mild side- effects were found in both groups withdifferent appearances. In group OFLX. 3 patients(10%)were found with some elevatedserum ALT and excited minds. In group CTX. phlebitis was detected in 4 patients(13. 33%).The drugsensitivity study in- vitro showed that the 2 drugs had excellent anti-bacterial effects on a majority of Gram- negative and Gram- positive pathogenic germs. Theresults indicated that OFLX and CTX were among the first selected drugs for the treatmentof lower respiratory infections.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第2期140-143,共4页
Chinese Journal of Antibiotics
