摘要
目的探讨血管内皮生长因子(vascular endthelial growth factor,VEGF)在分化型甲状腺癌中的表达及其与甲状腺癌临床病理特征之间的关系。方法采用免疫组化SP法检测57例分化型甲状腺癌、45例甲状腺良性病变和19例正常组织标本中的VEGF表达。结果VEGF在分化型甲状腺癌、甲状腺良性病变和正常甲状腺组织中的阳性表达率分别为86.9%、17.8%和10.5%,甲状腺癌中VEGF阳性表达与良性病变及正常组织相比差异均有统计学意义(P<0.05);VEGF强阳性表达在T3/T4、预后不良及复发组甲状腺癌中有更高的比例,差异有统计学意义(P<0.05),VEGF表达与预后指数呈正相关(r=0.320,P=0.015)。结论甲状腺组织中VEGF过表达可作为分化型甲状腺癌的一个辅助诊断和预后判断的指标,有助于预后不良的分化型甲状腺癌的筛选和鉴别。
Objective To investigate the relationship between the clinicopathological features and the expression of vascular endothelial growth factor （VEGF） in differentiated thyroid carcinoma （DTC）. Methods The VEGF expression was detected by immunohistochemistry in 57 DTCs （43 cases of papillary and 14 cases of follicular）, 45 hyperplastic lesions （31 cases of goiters, 12 cases of adenomas and 2 cases of Graves diseases） and 19 normal thyroid tissues that had been fixed in formalin and embedded in paraffin. Results The positive expression rate of VEGF was 86.9%, 17.8 % and 10.5 % in DTC, hyperplastic lesions and normal tissues, respectively. The expression of VEGF was significantly higher in cancer tissue than in hyperplastic lesions and normal tissues （ P 〈 0.05）. The proportion of overexpression of VEGF was higher statistically in T3/T4 stage, poor prognostic, recurrent cases than in control groups （ P 〈 0.05）. There was a positive correlation between the staining score of VEGF and the prognosis score of DTC （ r = 0. 320, P = 0. 015）. Conclusion The overexpression of VEGF is an auxiliary diagnosis and prognosis marker for DTC. To detect VEGF by immunohistochemistry facilitates us to identify poor-prognostic cases from DTC patients.
出处
《临床外科杂志》
2005年第8期497-499,i0001,共4页
Journal of Clinical Surgery
基金
广西自然科学基金资助项目(编号:0447065)
关键词
分化型甲状腺癌
血管内皮生长因子
免疫组化
thyroid differentiated carcinoma
vascular endothelial growth factor
immunohistochemistry
作者简介
江现强（1966-），男，硕士。主治医师。
