摘要
目的:通过检测胃癌及癌前病 变组织中端粒酶活性,探讨其在胃癌发 生发展中的作用及临床意义。方法:采 用SP免疫组化法检测40例胃癌和18 例癌前病变(其中慢性萎缩性胃炎伴肠 化生10例,非典型增生8例)端粒酶活 性。结果:胃癌及癌前病变中端粒酶阳 性率分别为92.5%(37/40)和33.3% (6/18),两者比较差异有统计学意义, P<0.05。端粒酶激活与胃癌的分化 程度、病理分期和淋巴结转移无明显相 关性,P>0.05。结论:端粒酶活性表 达与胃癌的发生密切相关,利用免疫组 化检测端粒酶活性可作为胃癌早期诊 断的参考指标,并应对阳性病例进行跟 踪随访。
OBJECTIVE： To explore the clinical significance of telomerase expression in the progression of gastric carcinoma through detection telomerase activity in gastric carcinoma and precancerous lesions. METHODS： Telomerase activity was determined by using the SP immunohistochemical technique in 40 cases of gastric cancer and 18 cases of gastric precancerous lesions （10 cases of chronic atrophic gastritis with intestinal metaplasia, 8 cases of dysplasia）. RESULTS： The positive rates of telomerase in gastric cancer and gastric precarcinoma were 92.5%（37/40） and 33.3%（6/18） respectively. There was a significant difference between the two groups, P〈0.05. There was no obvious correlation between telomeras activity and differentiation, pathological stage, lymph node metastasis of gastric carcinoma,P〉0.05. CONCLUSIONS： There may be a close relationship between telomerase activity expression and progression of gastric cancer. Detecting telomerase activity may serve as a reference index of gastric carcinoma early diagnosis by the SP immunohistochemistry, and the positive cases should be followed up.
出处
《肿瘤防治杂志》
2005年第4期283-285,共3页
China Journal of Cancer Prevention and Treatment
关键词
胃肿瘤
癌前状态
端粒
免疫组织化学
gastric neoplasms
precancerlous conditions
telomerase
immunohistochemistry
作者简介
冯艳玲，女，河南濮阳人，硕士，副教授，主要从事消化道肿瘤研究的工作。Tel：86-373-3029347；E-mail：FYL-HY@163.com。
