摘要
目的:研究桂枝茯苓丸对大鼠实验性子宫肌瘤的防治作用.方法:雌二醇0.2 mg/只隔日皮下注射复制大鼠子宫肌瘤模型,肾上腺素0.8 mg·kg-1皮下注射复制大鼠急性'血瘀症'模型.结果:桂枝茯苓丸(1.08～4.32 g·kg-1)灌胃能显著降低子宫肌瘤大鼠的子宫重量,抑制子宫平滑肌过度增殖,降低血清中雌二醇(E2)和孕酮(P)水平,抑制血小板聚集率;降低'血瘀症'大鼠的血液粘度,明显延长凝血时间、凝血酶原时间(PT)和白陶土部分凝血活酶时间(KPTT).结论:桂枝茯苓丸灌胃给药能抑制雌二醇诱导的大鼠子宫肌瘤的形成,与降低体内雌、孕激素水平及活血化瘀有关.
AIM： To study the preventive and cure effects of the guizhi fuling pellet （GFP） on rat hysteromyoma modes. METHODS： Estradiol 0.2 mg per rat was administrated by subcutaneous injection once a day to establish rat hysteromyoma model. 0.8 mg· kg^-1 adrenalin was administrated by subcutaneous injection to establish rat blood stasis model. RESULTS： GFP （ 1.08 - 4.32g· kg^-1 ） remarkably decreased uterus weight, restrained the excess proliferation of the smooth muscle of uterus, decreased the estradiol and progesterone in blood serum, restrained the platelet aggregation, and it significantly decreased the blood viscosity, prolonged blood coagulation time, kaolin partly theroboplastin time and prothrombin time of rats. CONCLUSION： GFP can restrain the formation of hysteromyoma, and the mechanism of GFP is related to decreasing the estrogen and progesterone, activating blood circulation to dissipate blood stasis.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第7期832-835,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
桂枝茯苓丸
雌二醇
子宫肌瘤
血瘀症
孕酮
guizhi fuling pellet
estradiol
hysteromyoma
blood stasis
progesterone
作者简介
李莉，通讯作者，女，硕士，讲师，研究方向：Tel：（0）13355513612 E-mail：llyy11972@163．com
