摘要
采用细胞毒效应ＤＮＡ荧光测定法与全血诱生ＴＮＦ检测技术，对３０例肺疾病人及１３例非癌胸病患者手术前后进行外周血自然杀伤细胞（ＮＫＣ）与肿名坏死因子（ＴＮＦ）活性的动态检测。结果表明：肺癌患者ＮＫＣ活性明显降低；手术后尤为如此，其降低的程度和持续时间与原发病变性质有关；而手术对ＴＮＦ影响较小，只有当肿瘤被彻底切除后，ＴＮＦ才随之下降。提示ＴＮＦ可作为判断肺癌手术的彻底程度和病人预后的一个指标。
TNF(tumor necrosis
factor)and NKC(natural killer cell)were used as the examiningparameters to study the cellular
immune status perioperatively in 30 patients vvith LC(LungCancer)and 13 cases of
noncancerous patients. The results showed that the NK activity inLC patients is seriously
inhibited,surgery may generally decrease the activity ofNK。The extent and time of NK activity
reduction are related to the quality of primary les-sion。As for the changes of TNF
activity,PBMC was activated under the presence of tumorto secrete a high level of TNF, while
surgical procedure had little effect on it.TNF de-creased only after the tumor was resected
completely. We consider that TNF may be used asaparameter to assess whether the lession is
resected completely and to predict the prognosisof the patient.
出处
《湖南医科大学学报》
CSCD
1995年第4期374-376,共3页
Bulletin of Hunan Medical University
关键词
肺肿瘤
外科手术
杀伤细胞
肿瘤坏死因子
lung
neoplasms
carcinoma
killer cell, natural
tumor necrosis fac-tor
surgery,operatlve
