摘要
利用显微荧光－阿达玛变换三维图像分析研究了Ｃｕ－ＴＳＰＰ、Ｍｎ－ＴＳＰＰ、Ｃｕ－ＴＭＡＰ、Ｍｎ－ＴＭＡＰ４种水溶性金属卟啉从细胞间质进入肿瘤细胞内的富集过程。对金属卟啉的自旋－晶格弛豫性能（Ｒ_１）的研究结果表明：Ｍｎ（Ⅱ）卟啉配合物的Ｒ_１值比Ｇｄ－ＤＴＰＡ提高了１．５～２倍。
The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems.Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting.Synthesis of targeting MRI contrast agents for specific tissue and organs is the most attractive field in the recent MRI studies.In this work,four water-soluble metalloporphyrins,Cu(Ⅱ)-TSPP,Mn(Ⅱ)-TSPP.Cu(Ⅱ)-TMAP,Mn(Ⅲ)-TMAP Were synthesized and their structures were confirmed by UV,IR,1H NMR and elemental analysis.Targeting to S180 tumor cells of these water-soluble porphyrins was studied in vitro by microscope fluorescence-Hadamard transform three-dimensional image analysis.The spin-lattice relaxivity(R1)of Mn(Ⅱ)-porphyrin chelate is 1.5-2 times larger than that of Gd-DTPA.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1995年第10期1629-1632,共4页
Chemical Journal of Chinese Universities
基金
国家"863"计划
关键词
金属卟啉
肿瘤
造影剂
MRI
磁共振诊断
Water-soluble metalloporphyrin,Tumor targeting,Microscope fluorescence-Hadamard transform three-dimensional image analysis,Spin-lattice relaxivity
