摘要
本实验采用沙土鼠双侧颈总动脉结扎模型观察急性脑缺血／再灌注期间脑内自由基代谢水平的变化。结果发现缺血４０ｍｉｎ时丙二醛（ＭＤＡ）含量明显增加，超氧化物歧化酶（ＳＯＤ）活性显著下降，谷胱甘肤过氧化物酶（ＧＳＨ－Ｐｘ）活性略有降低；再灌注１ｈ后ＭＤＡ含量进一步增加，ＳＯＤ活性进一步下降，ＧＳＨ－Ｐｘ活性也明显降低。结果表明脑缺血／再灌注期间脑内出现自由基代谢紊乱。
Free radical metabolic levels were observed in acute ischemia/reperfusion brain tissue induced by bilateral ligation of common carotid arteries of gerbils.It was found that after ischemia occurred for 40 minutes the content of malondiadehyde(MDA)significantly increased; the activity of superoxidte dismutase(SOD)evidently decreased: glu tathione peroxidase(GSH-Px)slightly decreased. After one-hour reperfusion the content of MDA further increased; the activity of SOD further decreased; the activity of GSH-Px significantly decreased too These results indicate that free radical metabolism in brain tissue becomes disordered during cerebral ischemia/reperfusion.
出处
《锦州医学院学报》
1995年第3期4-6,共3页
Journal of Jinzhou Medical College
关键词
脑缺血
再灌注损伤
自由基
gerbiljcerebral ischemia/reperfusion
free radical
