摘要
对40例胆石症患者进行HLA-A、B、DR、DQ抗原分型,发现患者组HLA-B13抗原频率较对照组显著增高。结果表明:中国东北汉族胆石症患者与HLA相关抗原为HLA-B13。进一步按结石部位、结石成分分组比较时,发现在各患者组中除了共同与HLA-B13抗原关联外,还分别与不同的HLA抗原关联:胆囊结石与DR3;胆管结石与A3、B35;胆固醇结石与DR3;胆色素结石与A3、DR7。结果提示胆囊结石、胆管结石、胆固醇结石、胆色素结石的易感基因可能存在于HLA不同的位点上。
An association between cholelithiasis and HLA was studied in 40 patients with cholelithiasis. We typed the HLA-A.B.DR and DQ antigens in 40 patients and the results were compared with those of 100 healthy subjects. HLA-B 13 was found much more frequently in patients than in control. The results suggest that patients with cholelithiasis in North-East Han Chinese could be associated with HLA-B 13 and the relative risk in patients was 5,4. Furthermore we divided the patients into following groups according to the place and the composition of stone to study HLA antigens, respectively and compared the results obtained with those of the controls. In addition to a common association with HLA-B 13 different groups were found to have association with different antigens,respectively :gallbladder stone group with DR3;bi!e duct stone group with A3,B35:cholesterol stone group with DR3;cholechrome stone group with A3 and DR7. This study showed that different HLA antigens were associated with different grorps of cholelithiasis patients. It might be possible that there are different susceptible genes linked to different loci of the HLA system.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
1995年第5期315-317,共3页
Chinese Journal of Microbiology and Immunology
关键词
胆结石
HLA
易感基因
Cholelithiasis
HLA
Susceptible gene
