摘要
目的探讨胎婴儿染色体异常与父母职业、年龄和遗传的关系,对生育过染色体异常患儿的父母做下次产前指导。方法对706例婴儿外周血和131例胎儿羊水细胞进行培养,收获的染色体作G显带,必要时加C带处理后分析染色体核型。结果101例胎婴儿染色体异常,其中新生儿95例占94.1%,胎儿6例占5.9%。染色体数目异常86例(其中21三体79例,18三体2例,13三体2例,21单体1例,部分三体1例,多倍体1例),结构异常15例。分析胎婴儿染色体异常与父母年龄与职业及遗传的关系,发现这些染色体异常的只有少数是母亲高龄及有染色体异常父母所生,绝大部分与父母的职业环境有关。特别是单纯21三体患儿,绝大多数父母年轻而且染色体无异常,是长期接触有机化学物质的年轻父母所生。结论父母职业环境对后代染色体会有一定影响。重点应对长期接触有机化学物质的年轻夫妇,如司机、电焊、维修、油漆和印刷、塑料工业的工人进行产前筛查和产前诊断,才能降低围产儿的出生缺陷,达到优生。
ObjectiveTo explore the influence of occupational environment, age and heredity of parents to the abnormality of chromosomes in the fetuses and infants. MethodsPeripheral blood from 706 infants and amniotic fluid cells from 131 fetuses were cultured and the karyotypes of the chromosomes with G-banding, and C-banding if necessary, were analyzed. Results101 cases of abnormal chromosomes including 95 in infants and 6 in fetuses were found, which showed 86 cases of chromosomes were abnormal in number, including 79 cases of trisomy 21, 2 cases of trisomy 18, 2 cases of trisomy 13, 1 case of monosomy 21 and 1 case of partial trisomy 21. Another 15 cases of chromosomes were abnormal in structure. The relation between the abnormity of fetus and infant chromosomes and the occupational environment, age and heredity of their parents was analyzed. Most of the abnormal chromosomes of the fetuses and infants, especially those with trisomy 21, related to the occupational environment of their parents, and a few were involved in advanced age of their mothers and abnormal chromosomes of their parents. ConclusionThe occupational environment could affect the chromosomes of their offspring. It is recommended that couples, who have long-term contacted with organic chemicals, such as drivers, electric welding workers,repairing workers, painters,printing workers and plastic producers should have a prenatal diagnosis, so that birth defect can be reduced and prepotency can be achieved.
出处
《中国职业医学》
CAS
北大核心
2005年第4期27-28,共2页
China Occupational Medicine
关键词
优生
染色体
化学物质
<Keyword>Prepotency
Chromosome
Chemical material
