摘要
用中国白兔２４只，在股骨关书面造成６ｍｍ×８ｍｍ全层软骨缺损，分别进行游离骨膜自体移植和钻孔术。术后４、８周取材做组织学及电镜观察并进行比较。结果表明：（１）钻孔、移植骨膜和对照组的优势修复组织分别为类透明软骨、幼稚软骨和纤维组织。（２）修复组织平均数量，移植骨膜明显优于钻孔和对照组。（３）骨膜移植、钻孔和对照组修复组织来源分别为骨膜本身、髓腔和软骨下骨及与缺损毗连的软骨。初步结论：移植骨膜和软骨下骨钻孔均能修复关节软骨缺员，单纯刮除后修复能力最差。
Abstract Full-thickness defects of 6mm ×8mrn were createdover the atticular surface of both femoral condyles in 24rabbits,Free periostum autografting and subchondralbone drilling were performed respectively over the ed-fects,except thpse of the control ones. They were,sac-rificeds postoperatively at 4 and 8 weeks, The newlyformed tissues in the defects were examined under lightandelecfron microscopes, The thickness of repair tis-sues(RT)were determined by stage micrometer, Thequantily and quality of the RT of different groups werecompared;the results were as follows:(1)Maturdehyalin-like cartilage wsa formed in the drilled cartilagedefects, immature cartilage was identified in the re-rioseeum grafted ones, and fibrous tissue was formed inthe controls.(2) The thickness and quality of RT ofthe periosteum gra fted defects exceeded that of the sub-chondral drilling and control ones.(3) RT in the drilleddefects seemed to arise from bone marrow, that in thegrafted defects, from the peniosteum itself.and that ofcontrols from. the stibchondral bone. It is preliminarlyconcluded tlar both freeperiosteum autografting andsubchondral bone drilling were feasible for repair of thefull-thickness articular cartilage defects. When the de-fects was leftalcne,tissue regeneration was much lessand the repair in-sufficient.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1995年第7期454-457,共4页
Chinese Journal of Orthopaedics
基金
美国CMB基金
