摘要
比较了几个品种葛根的ＬＤ＿（５０），云南葛的毒性最大，峨嵋葛和野葛次之，粉葛的毒性最小。抑制２，４－二硝基苯酚引起的大鼠体温升高，以野葛、峨嵋葛和葛根素的作用快速而明显，维持约８个小时。粉葛的作用较弱。对垂体后叶素引起的心肌缺血率，以峨嵋葛的作用最强，野葛和葛根素次之，粉葛的作用最弱。野葛和峨嵋葛的解热和抗心肌缺血作用均明显高于粉葛，葛根素是有效成分之一。
Through comparative studies on the acute toxicity of four species of Pueraria, it was found that thetoxicity of P. peduncularis was the highest, followed by P.lobata and P.omeiensis, and that of P.thomsonii was thelowest. The inhibitory effects of P. lobata, P.omeiensis and puerarin on the fever induced by 2, 4-dinitrophenol in ratswerevery fast and significant, maintaining for about 8 hours, while the effect of P.thomsonii is relatively weak. As forinfluence upon the degrees of myorardiac ischemia induced by pituitrin, P.omeiensis appeared to be the most potent,and P.thomsonii the least one, while P.lobata and puerarin were intermediate between the above two. Summarily, theantipyretic and anti-myocardiac ischemia effects of P.lobata and P.omeiensis are stronger than those of P.thomsonii,and puerarin is one of their effective components.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1995年第10期619-621,共3页
China Journal of Chinese Materia Medica
关键词
野葛
粉葛
峨嵋葛
云南葛
葛根素
药理
Pueraria lobata
P. thomsonii
P.omeiensis
P.peduncularis
puerarin
