摘要
目的通过对我院ICU病原菌分布及耐药性分析,为临床医生选择安全有效的抗菌药物提供依据。方法检测2002年1月～2004年12月ICU标本1305份,标本经分离培养,用ATBExpression细菌鉴定仪鉴定,用相应的ATB药敏试条进行药敏试验。结果检出1147株细菌中,G-杆菌为868株,占76%,G+球菌172株,占19%,酵母样真菌107株,占9.3%。大肠埃希菌和肺炎克雷伯菌ESBLs产生率分别为2002年为72.7%和88%,2003年为92.8%和95.8%,2004年为92%和90.3%。非发酵菌主要为铜绿假单胞菌和嗜麦芽寡养单胞菌,耐药情况严峻。G+球菌主要有金黄色葡萄球菌和凝固酶阴性葡萄球菌(包括溶血葡萄球菌和表皮葡萄球菌)及肠球菌,MRSA分别为2002年75.5%,2003年83.3%,2004年89.7%,未检出耐万古霉素肠球菌(VRE)。结论ICU病原菌多为多重耐药性,临床医生应重视病原菌送检,合理使用抗菌药物。
Objective To study the bacterial distribution and drug resistance in ICU of our hospital, the provide a base to guide drug use. Methods A totle of 1305 strains from Jan. 2002 through Dec. 2004 in ICU were isolated and analyzed with ATB Expression, and drug sensitivity test was performed. Results Among the 1147 bacterial isolates, Gram negative bacteria were 868(76%), and Gram positive 172(19%); Fungi was 107(9.3%). Escherichia accounted for 72.7% in 2002, 92.8% in 2003, and 92% in 2004. Klebsiella ESBLs accounted for 88% in 2002, 95.8% in 2003, and 90.3% in 2004.Nonfermentative bacilli mainly were pseudomonas aeruginosa and Stenotrophomonas maltophilia, which exhibited high drug resistance. Gram positive cocci mainly was Staphylococcus aureus and meticillin-resistant coagulase-negative staphylococcus (including Stayphylococcus haemolyticus and Staphylococcus epidermidis) and Enterococcus, Methicillin-resistant Staphylococcus Aureus (MRSA) accounted for 75.5% in 2002, 83.3% in 2003, and 89.7% in 2004, no Vancomycin-resistant Enterococcus (VRE) was found . Conclusion Most of bacterial infections in ICU have a high antibiotics resistance rate. Clinicians should discern the offering strains and use chemotherapy correctly.
出处
《实用预防医学》
CAS
2005年第4期781-783,共3页
Practical Preventive Medicine
关键词
ICU
病原菌分布
耐药性
ICU
Bacterial distribution
Drug resistance
