摘要
目的观察卡维地洛对不稳定型心绞痛患者内皮素(ET)、一氧化氮(NO)及血管性假血友病因子(vWF)水平的影响。方法不稳定型心绞痛患者62例采用完全随机化方法分成对照组(30例)和治疗组(32例),在常规抗血小板、扩血管治疗基础上,对照组予美托洛尔(12.5mg,每日2次×3d)口服,治疗组口服卡维地洛(6.25mg,每日2次×3d)。在治疗前后分别用放射免疫法测定ET;硝酸还原酶法比色测量血清NO浓度;ELISA法测定vWF值。结果对照组和治疗组在治疗前ET、NO、vWF差异均无显著性(P>0.05);用药后两组ET、NO、vWF与用药前比较,差异有显著性(P<0.05)。治疗组在用药后ET明显低于对照组,NO高于对照组(P<0.05)。结论卡维地洛可显著降低不稳定型心绞痛患者的ET、vWF水平,升高NO水平,改善内皮功能。
Objective To observe the effect of carvedilol on the serum levels of endothelin (ET),nitric oxide (NO) and von Willebrand factor (vWF) in patients with unstable angina pectoris (UAP).Methods 62 patients with UAP were randomly divided into two groups.On the basis of antiplatelet and vasodilator therapy,30 patients in control group were given metoprolol,while 32 patients in treatment group were administered with carvedilol.Before and after treatment,venous blood sample was taken,and the levels of serum ET-1,NO,and vWF were detected.Results There was no significant difference in the levels of ET,NO and vWF between control group and treatment group before treatment.After treatment,the levels of ET,vWF in control group and treatment group were significantly lower than those before treatment,howerer, the levels of NO in both groups were higher than those before treatment (P<0.05).After treatment,the levels of ET in treatment group were significantly lower than those of control group, and the levels of NO was higher than those of control group.Conclusion Carvedilol can decrease the serum levels of ET and vWF in patients with UAP,and increase serum levels of NO.
出处
《河北医药》
CAS
2005年第7期495-496,共2页
Hebei Medical Journal
关键词
卡维地洛
不稳定型心绞痛
内皮功能
治疗
carvedilol
unstable angina pectoris
endothelin
nitric oxide
von willebrand factor
