摘要
用免疫组化方法研究４６例新鲜胃癌标本中钙依赖细胞粘附分子（Ｅ─Ｃａｄｈｅｒｉｎ，Ｅ─ＣＤ）的表达，发现Ｅ─ＣＤ在６１％（２８／４６例）胃癌中呈减少至消失表达；而在正常胃小凹上皮，慢性胃炎上皮及肠化腺体中则呈均质保留表达；在７７％（１７／２２例）阂氏膨胀型胃癌中呈保留表达；在１００％（２４／２４例）闵氏浸润型中呈减少至消失表达；单个分散状态的癌细胞Ｅ─ＣＤ常常消失。此表达与不同分化程度胃癌的表达一致，表明钙依赖粘附分子的存在与否，可能决定着胃癌的生长方式和分化程度。
n this study,calcium dependent intercellular adhesion molecule,E─Cadherin(E─CD),was exam- ined immunohistochemically in 46 resected gastric cancer specimens.It was found that 61 % (28 / 46) of the specimens showed a reduction or even absence of E─CD expression, whereas in the intact gastric mucosa adjacent to the tumor including the gastric foveolae epithelia, epithelia of chronic gastritis and intestinal metaplasia grandular epithelia,E─CD expression was well preserved.However,further analysis revealed that 77%(17 / 22)of Ming's expanding type gastric cancer retained E─CD expression, while Ming's infiltrative type of gastric cancer lost all E─CD expression(100%, 24 / 24).Single scattered cancer ells usually lack the expression of E─CD. The E─CD expression correlates with gastric cancer cell differentiation,It is concluded that presence or absence of calcium dependent intercellular adhesion mole- cules could detennine the growth pattern of gastric cancer and degree of cell differentiation.
出处
《中华病理学杂志》
CSCD
北大核心
1994年第3期132-134,T030,共3页
Chinese Journal of Pathology
