摘要
目的:研制α-细辛脑前体脂质体。方法:采用冷冻干燥法,选择甘露醇/蔗糖做冻干剂,制备α-细辛脑前体脂质体, 并考察水化后脂质体的形态、粒径分布、黏度和包封率。结果:α-细辛脑前体脂质体经水化后,脂质体粒径分布均匀,平均粒径为0.655αm,粘度为1.6 mPaS,药物包封率约96%。结论:冷冻干燥法可用于α-细辛脑前体脂质体的制备。
Objective: To prepare α-asarone proliposomes and to be used as nasal drug delivery system. Method: Freeze-drying method was used to prepare α-asarone proliposomes. The particle morphology,the size range,viscosity and encapsulation efficiency of α-asarone liposomes were studied. Result: The α-asarone liposomes was formed after α-asarone proliposomes was hydrated,. The particles were distributed homogenously. The average particle size was 0. 655 μm, viscosity 1. 6 mPaS and encapsulation efficiency 96% . Conclusion: The freeze-drying method is a good method to prepare α-asarone proliposomes.
出处
《中国药师》
CAS
2005年第7期570-572,共3页
China Pharmacist
