摘要
目的探讨碱性成纤维细胞生长因子 (bFGF)和丹参对反复高 +Gz暴露致脑损伤的防护作用。方法选用 2 0 0 g左右的SD大鼠 ,在 +Gz暴露前后分别给予腹腔注射bFGF( 1 0 0 μg/kg)或丹参 ( 1 5g/kg)各一次 ,置动物离心机离心后不同时间处死 ,测定脑组织兴奋性氨基酸 (EAAs)及一氧化氮 (NO)的含量和凋亡细胞数 ,并与对照组和生理盐水组的测定值比较。结果 +Gz暴露组的EAAs、NO含量和凋亡细胞数明显高于对照组 ,而bFGF和丹参处理组的测定值明显低于 +Gz暴露组和生理盐水处理组。结论bFGF和丹参能降低 +Gz暴露后脑内EAAs和NO的含量及凋亡细胞数 ,对 +Gz暴露所致脑损伤具有保护和修复作用。
Objective To investigate the preventive and theralseutive effects of basic fibroblast growth factor (bFGF) and Radix Salviae Miltiorrhizae (RSM) on brain injury caused by repeated +Gz exposures. Method bFGF and RSM were injected intraperitoneally into SD rats before and after repeated +Gz exposures. The contents of excitatory amino acids (EAAs), nitric oxide (NO) and the number of cell apoptosis in the brain were measured,and were compared to those of the control group and normal saline (NS) group. Result The contents of EAAs, NO and the number of cell apoptosis were significantly higher in repeated +Gz exposures group than those in control group. The values were markedly lower in bFGF and RSM group than those in repeated +Gz exposures group and NS group. Conclusion bFGF and RSM showed distinct preventive and therapeutic effect on the brain injury induced by repeated +Gz exposures.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2001年第2期137-139,共3页
Space Medicine & Medical Engineering
基金
全军医药卫生科研基金课题! ( 98D0 3 3 )
空军后勤部科研基金课题!(KH99190 76)
关键词
碱性成纤维细胞
生长因子
丹参
正加速度
兴奋性氨基酸
一氧化氮
细胞凋亡
basic fibroblast
growth factor
Radix Salviae Miltiorrhizae
positive acceleration
excitatory amino acids
nitric oxide
apoptosis
