摘要
目的研究高同型半胱氨酸血症对帕金森病的发病与药物治疗的影响。方法选择正常老年组30例和未治疗帕金森病(PD)患者组30例,应用高效液相色谱法测定血浆同型半胱氨酸(hcy)水平。选择治疗中的PD患者60例,分为治疗组(应用美多巴)30例和对照组30例(应用其他抗震颤麻痹药物),同样方法测定其血浆中hcy水平。结果未治疗PD组、治疗组和对照组的hcy水平分别为:18.79±2.14、21.30±3.57和19.82±2.80,与正常老年组(12.31±1.26)比较显著升高(P<0.05),治疗组与未治疗PD组、对照组比较hcy水平无明显差异。结论高同型半胱氨酸血症是PD的危险因素,但对PD的治疗无明显影响。
Objective To study the effect of hyperhomocysteinemia on the occurrence and treatment with drugs in parkinson's disease( PD) patients.Methods Investigate plasma hcy level with high performance liquid chromatography in normal elder group 30cases and PD patients 30 cases without treatment.Next hcy level were detected similarly in 60 PD patients treated with levodopa 30 cases and other drugs 30 cases separately.Results Hcy level of the three PD groups,including without treatment,treated with levodopa and other drugs,were 18.79±2.14、21.30±3.57 and 19.82±2.80 separately.They were significantly higher compared to the one of normal elder group (12.31±1.26)(P< 0.05).It was no significant defference in PD patients treated with levolopa compared to with other drugs and without treatment.Conclusion Hyperhomocysteinemia is a dangerous factor of PD,but it has no obvious effect on PD treatment.
出处
《医药论坛杂志》
2005年第9期20-21,共2页
Journal of Medical Forum
