摘要
在HCl浓度为5.0×10-4mol/L时,磺胺乙酰钠-NaNO2-1-萘胺的重氮化偶合反应,生成不稳定的红色产物,利用顺序注射停留技术在473nm波长处检测该不稳定产物,建立了快速自动测定磺胺乙酰钠的新方法。该方法线性范围为5～2500μg/mL,检出限为0.018μg/mL,进样频率为62个/h。应用于药物中磺胺乙酰钠的测定,并与药典规定方法进行对照。
A rapid and simple sequential-injection spectrophotometric method using stopped-flow technique for the determination of sulfacetamide sodium was described. This method was based on the diazotisation of sulfacetamide sodium with sodium nitrite and coupling with 1-naphthylamine in 5.0×10^(-4) mol/L of hydrochloric acid. The measurements of unstablered product of the reaction were performed at 473 nm. The linear range was 5～2500 μg/mL, and the detection limit was 0.018 μg/mL. The method was applied to the determination of sulfacetamide sodium in drugs with the sample throughput of 62 h. The results were statistically compared with those obtained by pharmacopoeia method.
出处
《分析试验室》
CAS
CSCD
北大核心
2005年第6期72-74,共3页
Chinese Journal of Analysis Laboratory
关键词
顺序注射分析
停留技术
分光光度法
磺胺乙酰钠
1-萘胺
Sequential-injection analysis
Stopped-flow technique
Spectrophotometry
Sulfacetamide sodium
1-naphthylamine
