摘要
７０例慢性特发性血小板减少性紫癜（ＩＴＰ）患者根据其常规骨髓涂片检查及巨核细胞（ＭＫ）标化计数分为ＭＫ增高３８例，ＭＫ正常２４例和ＭＫ降低８例３组。结合骨髓切片免疫图像分析和巨核祖细胞体外培养，对ＩＴＰ患者的巨核细胞及临床预后进行了研究，发现：ＭＫ增高组骨髓各阶段ＭＫ增多，爆式巨核细胞集落（ＢＦＵ－ＭＫ）及巨核祖细胞集落（ＣＦＵ－ＭＫ）正常。ＭＫ正常组前原始及原始ＭＫ偏低，ＢＦＵ－ＭＫ降低。ＭＫ降低组各阶段ＭＫ减少，ＢＦＵ－ＭＫ，ＣＦＵ－ＭＫ显著降低。临床上ＭＫ增高组对泼尼松疗效较好，而ＭＫ正常组和ＭＫ降低组的治疗效果差。
n the basis of standardization of megakaryocyte(MK)count in routinely examining bone marrow smears70 thrombeytopenia cases were classified into threegroups:the group with increased number of MK (38),the group with normal number of MK (24) and thegroup with decreased number of MK(8).MK of vari-ous stages was further studied by means of immunomor-phometric method and in vitro megakaryocytopoiesis.The results showed:In the group with increased MK,the number of various stages MK was markedly in-creased,but the number of BFU-MK and CFU-MK wasnormal.Promegakaryoblasts and megakaryoblasts wereslightly decreased and the number of BFUMK was de-various stages MK in the group with decreased MK wassignificantly decreased,so were BFU-MK and CFU-MK. The patients in the group with increased MK re-sponded well to prednison,but the result of the treat-ment was unsatisfied in the groups with normal and de-creased MK.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第5期251-253,共3页
Chinese Journal of Hematology
基金
胡应洲基金
