摘要
应用放免法测定了２０名正常人、１８例胃溃疡（ＧＵ）和３１例十二指肠溃疡（ＤＵ）患者的血浆（空腹和餐后）、胃液和胃十二指肠粘膜组织的神经降压素（ＮＴ）含量。结果发现，正常人血浆ＮＴ含量较高，胃液较少，胃窦和十二指肠粘膜组织含量相近；胃液中ＮＴ可能来源于胃粘膜Ｎ细胞的直接分泌和血液弥散；试餐刺激后３０分钟血浆ＮＴ含量无明显变化。ＧＵ和ＤＵ患者血浆、胃液和胃窦、十二指肠粘膜ＮＴ含量明显减少，由此引起胃十二指肠粘膜所受侵袭因素增强、防御机能减退，使ＧＵ和ＤＵ易于发生发展，且部分复合性溃疡可能来源于ＤＵ．
The concentration of neurotensin(NT)in plasma,gastric juice, antral and duodenalmucosa in fasting state among 20 normals,18 patients with gastric ulcer(GU)and 3l patientswith duodenal ulcer(DU)was measured by RIA,at the same time the influence of eating onNT in plasma was also observed.The results showed that among normals the NT was higherin plasma(fasting state 547.3± 98.3pg/ml),30 minutes after meal-stimulated 578.8±90.2pg/ml)than in gastric juice(100.5 ± 52.7pg/ml P<0.0001),but those in antral mucosa(124.9 ±39.2pg/mg and duodenal mucosa(132.4± 54.4pg/mg)had no significently difference(P>0.05).NTin gastric juice may come from N cells in the gastric mucosa and blood diffusion。Eating hasno obvious influence on plasma NT concentration of normals(P>0.05).Both in GU and DUgroups,NT in antral(GU 69.5± 17.4pg/mg, DU 64.1)±21.lpg/mg)and duodenal mucosa(GU85.1 ± 22.5pg/mg,DU 86.3 ± 33.lpg/mg),and in plasma in fasting(GU 442.3 ± 61.4pg/m1, DU474.0 ± 78.9pg/ml)and meal-stimulated(GU 467.6 ± 83.7pg/m1,DU 457.2 ± 96.7pg/m1)statesmarkedly declined(P< 0.00l for al1).This may cause a reduction of the protective effect onthe gastrointestinal mucosa and an increase in aggressive effects,and thus favor theformation of GU and DU.
出处
《中华消化杂志》
CSCD
北大核心
1994年第4期193-195,共3页
Chinese Journal of Digestion
