摘要
３４例皮肤混合瘤中１５例用１１种抗体作免疫组化研究，以便建立肿瘤的分类及阐明组织起 源。结果如下：①皮肤混合瘤基本可分为大汗腺型和小汗腺型，大汗腺型比小汗腺型远为常见。② 肿志的上皮成分可分为管腺性、实巢性及间质性上皮。管腺内层细胞有明显上皮特征，其角蛋白、癌 胚抗原（ＣＥＡ）及上皮细胞膜抗原（ＥＭＡ）均阳性，而外层细胞对结蛋白（Ｄｅｓｍｉｎ，Ｄｅｓ）、肌动蛋白 （Ａｃｔｉｎ）、ＣＥＡ及ＥＭＡ呈阴性，对波形蛋白（Ｖｉｍｅｎｔｉｎ，Ｖｉｍ）。Ｓ１００蛋白、细胞角蛋白（Ｃｙｔｏｋｅｒａｔｉｎ， ＣＫ，１１例）、神经原特异性烯醇化酶（ＮＳＥ，８例）及胶质纤维酸性蛋白（ＧＦＡＰ，６例）均呈阳性。间质细 胞与实巢上皮的免疫表达相似于管腺外层细胞，提示肿瘤的问质成分既可来自管腺的外层细胞，也 或来自多潜能干细胞，但不能证实为唯一肌上皮起源。
The clinicopathological features of 34 cases of cutaneous mixed tumor are reported. The specimens of 15 cases were studied immunohistochemically with 11 kinds of antibodies in order to establish their classification and to elucidate their histogenesis. The results were as follows: (1 ) Mixed tumors of the skin were basically apocrine or eccrine in type,apocrine type of mixed tumor was much more common than the eccrine one. (2)The epithelial elements of these tumors could be classified as tubuloglandular,solid nests and stromal cells. The inner cell layers of tubuloglandular components had distinct epithelial features,expressing keratin,carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA). The outer cell layers had negative results for actin , desmin, CEA , and EMA, and had positive results for vimentin, S100 protein, cytokeratin (11 cases ), neuron-specific enolase (8 cases ), and glial fibrillary acidic protein (6 cases). The immunophenotypes of stromal cells and solid nests were similar to those of the outer cell layers. These date suggest that the stromal components may derive either from the outer cells of the tubuloglandular elements or pluripotent stem cells, but can not confirm their exclusive myoepithelial origin.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1994年第2期72-75,共4页
Chinese Journal of Dermatology
关键词
汗腺肿瘤
病理学
免疫组织化学
Sweat gland neoplasms Pathology,clinical Immunohistochemistry
