摘要
为了观察小剂量环孢素Ａ（ＣｓＡ）对狼疮性肾炎（ＬＮ）的疗效，我们将ＣｓＡ与环磷酰胺（ＣＴＸ）冲击疗法作比较，两组各１５例。结果总体疗效相似，但在治疗初期，ＣｓＡ组的血沉下降、尿蛋白减少以及血清白蛋白上升比ＣＴＸ组快。ＣｓＡ能早期诱导ＬＮ临床缓解，减少皮质激素和ＣＴＸ用量及其相应的副作用。８例在ＣｓＡ减药期间或停药前加用ＣＴＸ冲击治疗，有效地防止了ＣｓＡ停药后的复发。研究表明，小剂量环孢素Ａ治疗狼疮性肾炎是一种有效的、可取的疗法。
he aim of this studv is to compare the effects of low dose cyclosporin A(CsA)and intravenous cyclophosphamide pulses(IV- CTX)in the treatment of lupus nephritis(LN).Thirty patients were in-cluded in the study with 15 in each group.The improvement of ESR and proteinuria and the increase of serum albumin were observed in the CsA group, but not in the IV～CTX group at the early stage of the therapy,though the overall effects were similar.The conclusion is that the use of low dose CsA could quench the activity of LN at the early stage of the therapy,reduce the doses of steroid and CTX and minimire their side effects.IV- CTX was added to 8 cases of LN before CsAtreatment had been tapered of or withdrawn.The results indicated that this regimen could effectively prevent the relapse of LN af-ter the withdrawal of CsA therapy,It is an effective and valuable therapy.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1994年第10期684-686,共3页
Chinese Journal of Internal Medicine
关键词
狼疮性肾炎
环孢素类
环磷酰胺
Lupus Nephritis Cyclosporins Cyclophosphamide
