摘要
本文报道了２９例慢性丙型肝炎（ＣＨＣ）患者采用重组α－干扰素（α－ＩＦＮ）每日６００万单位，疗程８周，于治疗前，治疗后即刻、３个月、６个月或１年，２年采集血清，测定丙型肝炎病毒核酸（ＨＣＶＲＮＡ）并动态观察其丙氦酸转氨酶（ＡＬＴ）的变化。结果表明：１２例（４１．４％）呈持续应答，ＨＣＶＲＮＡ持续阴转２年以上，ＡＬＴ亦持续正常；９例（３１．ｏ％）呈暂时应答；８例（２７．６％）为无应答反应。并提示血液中含有高滴度ＨＣＶＲＮＡ的ＣＨＣ患者可能对干扰素治疗较为敏感。
9 patients with chronic hepatitis C have been treated for eight weeks by using α-IFN(6×106U/d).The sera of the cases were collected at six periods of the medical exp-eriment,1.e. pre-treatment,beginning stage of the treatment,three months,six months,one year,and two years after the treatment. The HCV RNA as a marker of viral reprod-uction ,was then detected and the trend of ALT was also observed.The results showedthat l2 cases(41.4%)had continuous responses with negative reversion of HCV RNAfor more than two years. Simultaneously,the indicators of ALT for these patients werealso continuously normal.Of the 29 cases,9(31.0%)had temporary responses and 8cases(27.6%)showed no response. The study revealed that the patients with high titreHCV RNA sera might be more sensible to the treatment of α-IFN.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
1994年第2期74-77,共4页
Chinese Journal of Infectious Diseases
关键词
丙型肝炎
干扰素
丙型肝炎病毒
Chronic hepatitis C
a-interferon
Reverse transcriptase polymerase chain re- Cation
