摘要
目的:观察小檗碱(berberine,Ber)对豚鼠左心房和气管的作用。方法:采用离体豚鼠左心房和气管条实验,比较Ber与吡那地尔(pinacidil,Pin)的作用。结果:Ber呈浓度依赖性的增强左房收缩张力,而Pin则浓度依赖性的减弱左房收缩张力。Ber使氨甲酰胆碱(carbachol,Car)抑制左房收缩的累积量效曲线平行右移,最大反应(Emax)基本不变,而Pin使Car量效曲线左移;当两药同时存在时,量效曲线同对照组基本相同。在豚鼠气管,Ber使乙酰胆碱(acetylcholine,ACh)累积量效曲线左移,而Pin则使其右移,Emax不压低,当两药同时存在时,量效曲线同对照组基本相同。结论:Ber对钾通道有阻滞作用。
AIM: To observe the effects of berberine (Ber) on left atria and trachea in guinea pigs. METHODS: The experiment was carried out with isolated left atria and trachea in guinea pigs, and the effects and interactions were compared between Ber and pinacidil (Pin). RESULTS: Ber concentration-dependent increased the force of contractile, while Pin decreased the force. Ber leaded a parallel rightward shift in accumulated response curve of depression contraction of left atria by Car, and it hardly changed the maximum response (E_(max)), while Pin leaded a parallel leftward shift in the same curve. In the combination of Ber and Pin, the dose-response curve hardly changed as the control one. In isolated guinea pig trachea, Ber caused a leftward shift in the dose-response curve of ACh, whereas Pin produced a rightward shift in the same curve without changing E_(max). When both Ber and Pin existed in the same container, there was no modification in the response to ACh. CONCLUSION: Ber shows the effect of blocking potassium channel.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第5期567-569,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
小檗碱
吡那地尔
左心房
气管
量效曲线
berberine
pinacidil
left atria
trachea
dose-response curve
