摘要
为评价急性早幼粒细胞白血病(APL)PML/RARα异型与临床治疗及预后的相关性,对71例诱导治疗的APL患者定期进行血像、骨髓像检查,用巢式RT-PCR检测PML/RARα不同转录本。结果表明:短型(S)和V型白细胞总数比长型(L型)显著升高,所以较易早期发生严重的出血合并症。S型和V型PML/RARα患者的复发率高于L型患者。结论:APL患者PML/RARα异型可作为独立的预后因素。
To evaluate the relation of PML/RARα isoforms in adult APL patients to clinical therapy and prognosis, the picture of blood and bone marrow aspirates for 71 APL patients treated by induction therapy were peridically examined and the different transcripts of PML/RARα were assayed by nested RT-PCR. The results showed that the median WBC count (×109 /L) in the patients with the short (S) and variable (V) isoform were significantly higher than that in long (L) isoform. So, the serious bleeding complications early occurred. Relapse risk for patients with S and variable isoforms were higher than that with L isoform. In conclusion, PML/RARα isoforms in patients with APL may be the independent prognostic factor.
出处
《中国实验血液学杂志》
CAS
CSCD
2005年第3期500-502,共3页
Journal of Experimental Hematology
